Comments on: The E2 Mechanism

By: Ayushi Chaudhary

Ayushi Chaudhary — Mon, 04 Mar 2024 17:18:35 +0000

Hello sir
In bromocyclohexane , if at one ortho position bromine is anti-periplaner with hydrogen and on the other ortho, with Deuterium then which will be a fovoured (major) compound formed ??

By: E1 vs E2: Comparing the E1 and E2 Reactions | Straight A Mindset

E1 vs E2: Comparing the E1 and E2 Reactions | Straight A Mindset — Fri, 08 Dec 2023 00:00:32 +0000

[…] that we’ve gone through the mechanisms of the E1 and E2 reactions, let’s take a moment to look at them side by side and compare […]

By: Antiperiplanar and E2 Reaction Relationship | UO Chemists

Antiperiplanar and E2 Reaction Relationship | UO Chemists — Tue, 07 Nov 2023 21:42:07 +0000

[…] of the same plane within the molecule. This geometric arrangement is often associated with the E2 elimination reaction, where a leaving group and a proton are removed from adjacent carbon atoms. Understanding […]

By: hans

hans — Thu, 18 May 2023 13:54:40 +0000

Is a big benefits to read this O-Chem site.

By: James Ashenhurst

James Ashenhurst — Mon, 10 Oct 2022 17:20:38 +0000

In reply to Sundar Naga.

I agree that a mechanism is a theory, and theories help us make sense of facts that are observed. I also think that theories can never be proven, only disproven.

When I use the word “clue”, I am using it somewhat colloquially as a synonym for “evidence”. The rate law represents experimental data that any postulated mechanism has to be consistent with.

I don’t really see a problem with using the word “clue” here. Facts are clues. Figuring out a mechanism can be a bit like figuring out a puzzle. Based on what I’m reading in your comment, I don’t see a good enough reason to replace the word.

By: Sundar Naga

Sundar Naga — Sat, 08 Oct 2022 12:41:33 +0000

I have been a big fan of Master Organic Chemistry. You are doing a great job. Just wanted to point out something very important. The reason for chemists imagining a possible mechanism for a given type of reaction is to explain, make sense of the rate law. After such a mechanism is postulated it is found that it is capable of explaining many other facts related to that reaction. Mechanism is a theory and the sole goal of any theory is to explain, help us make sense of facts observed. Therefore, please avoid using the term clues to the mechanism. The rate law is not a clue to the mechanism in the sense that there is some other goal for talking about the mechanism and the rate law becomes one of the clues to achieve this goal. No. The rate law is the very reason for coming up with a possible mechanism which then happens to explain so many other facts. Please replace the term clue with explanation.

By: James

James — Fri, 08 Feb 2019 02:25:30 +0000

In reply to Amelia. That's right, because you're destroying stereocenters, not making them!

By: Siddarth

Siddarth — Sun, 06 May 2018 18:56:08 +0000

In reply to Varun. @Varun this is because the transition state has an alkene-like structure. I am sure of the fact that 3>2>1, but I cannot illustrate the diagram here. You should look it up in a reference book if you still doubt it

By: Dave Townsend

Dave Townsend — Thu, 25 Jan 2018 11:21:36 +0000

If the Morse Potential allows bond breaking, by spectroscopic stretching and rotation; could this allow the disruption of inter and intra molecular attachments?
In turn, could selection of an appropriate bond, application of correct downfield absorption, and suitable reduced mass point, allow complex bond breaking?
Also, would the molecular resonance be tolerable and penetrable in organisms?
If you follow my drift?

By: Nesreen

Nesreen — Fri, 23 Dec 2016 06:28:14 +0000

Thanx a lot....I understood these reactions at last .??