Comments on: The E1 Reaction https://www.masterorganicchemistry.com/2012/09/19/the-e1-reaction/ Tue, 16 Apr 2024 18:36:55 +0000 hourly 1 https://wordpress.org/?v=6.6.2 By: James Ashenhurst https://www.masterorganicchemistry.com/2012/09/19/the-e1-reaction/#comment-689036 Thu, 28 Mar 2024 15:09:06 +0000 https://www.masterorganicchemistry.com/?p=5988#comment-689036 In reply to Harsh Chauhan.

1) If your substrate is an alkyl halide, you just want to look for a polar protic solvent (e.g. EtOH, H2O, CH3OH) and *heat*.
2) If you have an alcohol instead of an alkyl halide, look for a strong acid such as H2SO4 or H3PO4 (which have non-nucleophilic conjugate bases) and heat.

That’s pretty much it!

]]> By: Harsh Chauhan https://www.masterorganicchemistry.com/2012/09/19/the-e1-reaction/#comment-688995 Thu, 28 Mar 2024 05:34:51 +0000 https://www.masterorganicchemistry.com/?p=5988#comment-688995 which type of reagents gives the E1 reactions?

]]> By: Deciding SN1/SN2/E1/E2 (1) – The Substrate | Straight A Mindset https://www.masterorganicchemistry.com/2012/09/19/the-e1-reaction/#comment-679086 Fri, 08 Dec 2023 00:03:36 +0000 https://www.masterorganicchemistry.com/?p=5988#comment-679086 […] Deciding whether a reaction is SN1/SN2/E1/E2 first of all requires understanding the bonds that form and break in each of these four reactions and the key features of their mechanisms (Review here – SN1 / SN2 / E1 / E2) […]

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2012/09/19/the-e1-reaction/#comment-634445 Mon, 01 Aug 2022 20:36:03 +0000 https://www.masterorganicchemistry.com/?p=5988#comment-634445 In reply to Minnoli.

OK, glad you have found them helpful Minnoli!

]]> By: Minnoli https://www.masterorganicchemistry.com/2012/09/19/the-e1-reaction/#comment-633960 Sun, 24 Jul 2022 16:01:29 +0000 https://www.masterorganicchemistry.com/?p=5988#comment-633960 These posts are so amazing. Thank you SO much!

]]> By: Elimination ReactionsThe E2 Mechanism – A to Z Chemistry https://www.masterorganicchemistry.com/2012/09/19/the-e1-reaction/#comment-586758 Sat, 24 Oct 2020 02:52:55 +0000 https://www.masterorganicchemistry.com/?p=5988#comment-586758 […] gone through the E1 mechanism for elimination reactions, we’ve accounted for one way in which elimination reactions can occur. However, there’s still […]

]]> By: Elimination Reaction: Definition, Examples, Mechanism, and Applications https://www.masterorganicchemistry.com/2012/09/19/the-e1-reaction/#comment-575916 Wed, 05 Feb 2020 06:34:27 +0000 https://www.masterorganicchemistry.com/?p=5988#comment-575916 […] E1 reaction mechanism –Masterorganicchemistry.com […]

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2012/09/19/the-e1-reaction/#comment-569412 Thu, 31 Oct 2019 20:35:26 +0000 https://www.masterorganicchemistry.com/?p=5988#comment-569412 In reply to Lindsey.

An E2 – certainly, because it’s controlled by stereochemistry. A good example would be in some substituted cyclohexanes where there is only one hydrogen anti (trans) to the leaving group.

An E1 (the topic of this post) – the best situation would be one where only one alkene is possible as a product. For example the E1 reaction of C6H5-CH(OH)-CH3 would only give one alkene.

Otherwise, the selectivity is going to be determined by the difference in stability between the alkenes, and since that’s usually quite small, 70:30 or 80:20 ratios are common.

]]> By: Lindsey https://www.masterorganicchemistry.com/2012/09/19/the-e1-reaction/#comment-569325 Thu, 31 Oct 2019 03:04:07 +0000 https://www.masterorganicchemistry.com/?p=5988#comment-569325 would it be possible to make it so that an E2 reaction results in only one product (vs major and minor products)? if so, how would this be done?

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2012/09/19/the-e1-reaction/#comment-561974 Wed, 28 Aug 2019 02:47:31 +0000 https://www.masterorganicchemistry.com/?p=5988#comment-561974 In reply to Nidhi.

Yes, since HO- is a strong base, it will go down the E2 pathway instead of the E1 pathway.

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