Comments on: Hammond’s Postulate

By: Hammond Postulate: Statement, Structure, and Applications

Hammond Postulate: Statement, Structure, and Applications — Wed, 01 May 2024 05:46:56 +0000

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By: James Ashenhurst

James Ashenhurst — Tue, 25 Jun 2019 03:49:01 +0000

In reply to M Azhar ansari. What do you think? What is the first step in the SN1 reaction? What would be the first step in the ArSN1 reaction? What's an example of a molecule that would undergo the ArSN1 reaction? Exercises for you.

By: M Azhar ansari

M Azhar ansari — Sat, 22 Jun 2019 11:13:51 +0000

The first step of ArSN1 is revesible , irreversible ,first order or zero order?

By: James Ashenhurst

James Ashenhurst — Thu, 18 Apr 2019 20:16:46 +0000

In reply to Richard Feinman.

Yes, I should have written exergonic. Thank you for the clarification.

Re the second, I’d disagree. Thermodynamic stability does not necessarily correlate with kinetic instability. Human beings are “unstable” relative to our combustion with oxygen to give CO2 and H2O, but the activation barrier is quite high.
However one could say that a reactive intermediate en route to combustion will be very similar to the transition state of the reaction itself.

By: Simon

Simon — Wed, 16 Jan 2019 15:47:20 +0000

Thank you.

What is the significance of the Hammond’s postulate? Would you be so kind to give an example, say, of proposed reaction mechanism, which is explicitly justified by Hammond’s postulate.

By: Vidhi Patel

Vidhi Patel — Tue, 27 Nov 2018 12:36:36 +0000

Could you explain how to determine which alkene forms carbocation faster in Hammonds postulate?

By: Richard Feinman

Richard Feinman — Wed, 21 Nov 2018 22:01:20 +0000

Don’t you mean exergonic rather than exothermic?
Also, my understanding of the practical application of Hammond postulates that a compound that is thermodynamically unstable, breaks down easily is also kinetically unstable, reacts quickly. I think this is the same as what you wrote. Yes?

By: Mimi

Mimi — Sun, 15 Mar 2015 04:55:17 +0000

Excellent explaination, thank you for helping out.

By: shristy tiwary

shristy tiwary — Wed, 03 Apr 2013 12:38:34 +0000

will you plz..explain..How Hammond’s postulate ableto explain the similarity of structure with the substrate and product?

By: jetharamjaipal(jodhpur)

jetharamjaipal(jodhpur) — Sat, 05 Nov 2011 14:54:57 +0000

BIG THANKS OF YOU FOR MY help