Comments on: Why organic chemistry is hard (2) https://www.masterorganicchemistry.com/2011/04/14/why-organic-chemistry-is-hard-2/ Fri, 07 Oct 2022 00:26:39 +0000 hourly 1 https://wordpress.org/?v=6.6.2 By: James Ashenhurst https://www.masterorganicchemistry.com/2011/04/14/why-organic-chemistry-is-hard-2/#comment-552497 Fri, 12 Apr 2019 19:47:16 +0000 https://www.masterorganicchemistry.com/?p=1484#comment-552497 In reply to Nagina.

OK, I’m glad you find the site helpful Nagina!

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2011/04/14/why-organic-chemistry-is-hard-2/#comment-552496 Fri, 12 Apr 2019 19:46:59 +0000 https://www.masterorganicchemistry.com/?p=1484#comment-552496 In reply to josy malone.

I think I need more context from you here. Why would you deliberately be adding CO2 to a reaction for the formation of a secondary alcohol?

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2011/04/14/why-organic-chemistry-is-hard-2/#comment-552495 Fri, 12 Apr 2019 19:44:23 +0000 https://www.masterorganicchemistry.com/?p=1484#comment-552495 In reply to Steve.

Generally, additions to carbonyls are faster than removal of the alpha proton unless the carbonyl is sterically hindered. One reason it’s not faster is that the C-H is only acidic when it’s in a conformation where the bond is aligned with the p-orbitals of the carbonyl.

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2011/04/14/why-organic-chemistry-is-hard-2/#comment-552494 Fri, 12 Apr 2019 19:43:12 +0000 https://www.masterorganicchemistry.com/?p=1484#comment-552494 In reply to Chris McKenna.

Changed it. Thank you!

]]> By: Nagina https://www.masterorganicchemistry.com/2011/04/14/why-organic-chemistry-is-hard-2/#comment-526244 Wed, 10 Jan 2018 10:52:08 +0000 https://www.masterorganicchemistry.com/?p=1484#comment-526244 Your explanation is way better than my organic lecturer! thank you so much for making everything so simple!

]]> By: Chris McKenna https://www.masterorganicchemistry.com/2011/04/14/why-organic-chemistry-is-hard-2/#comment-429367 Wed, 07 Oct 2015 18:06:29 +0000 https://www.masterorganicchemistry.com/?p=1484#comment-429367 In the sentence above which begins “So at the end of the day you end up with a product where two equivalents of Grignard have added…”, it might be clearer to say “So at the end of the day you end up with a product where two equivalents of Grignard have added to the starting ester…”

This is a really good website, keep up the good work.

]]> By: Elizabeth https://www.masterorganicchemistry.com/2011/04/14/why-organic-chemistry-is-hard-2/#comment-421420 Wed, 02 Sep 2015 02:34:21 +0000 https://www.masterorganicchemistry.com/?p=1484#comment-421420 Your site is very clear and helpful!! I love that each step is clearly explained and the colors and numbers are so easy to follow. Thank you!!!!!

]]> By: jatin https://www.masterorganicchemistry.com/2011/04/14/why-organic-chemistry-is-hard-2/#comment-339816 Sat, 13 Dec 2014 21:32:24 +0000 https://www.masterorganicchemistry.com/?p=1484#comment-339816 thanks a lot! great article. thanks for covering all possible details.

]]> By: Steve https://www.masterorganicchemistry.com/2011/04/14/why-organic-chemistry-is-hard-2/#comment-93854 Fri, 09 May 2014 12:45:15 +0000 https://www.masterorganicchemistry.com/?p=1484#comment-93854 If the alpha hydrogen on a ketone or aldehyde has a pka of around 17-19, why wouldn’t the carbanion (a very strong base) abstract a alpha hydrogen.

]]> By: Manuela https://www.masterorganicchemistry.com/2011/04/14/why-organic-chemistry-is-hard-2/#comment-59815 Thu, 26 Dec 2013 22:09:25 +0000 https://www.masterorganicchemistry.com/?p=1484#comment-59815 Great article! Thank you :-)

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