Comments on: The Organic Chemistry Reagent Guide is here!

By: Sophie Downey

Sophie Downey — Mon, 11 Jul 2022 17:25:44 +0000

On the page about DCC coupling, page 29, It shows the carboxylic acid attacking the DCC first, and then a proton transfer occurring afterwards between the =OH+ and the N- intermolecularly, even though they not realistically going to have a proton transfer. I found another source that showed the proton transfer occurring first between a nitrogen and the carboxylic acid intramolecularly, which seems a lot more feasible.
Here’s the Chemistry Steps version of the mechanism. It makes a lot more sense.
https://www.chemistrysteps.com/amides-from-carboxylic-acids-dcc-edc-coupling/

By: Utkarsh Ojha

Utkarsh Ojha — Fri, 28 Aug 2020 09:50:07 +0000

A very great reagent guide sir, but I am not able to afford it. Keep up the good work, you are already helping many students. I can’t ask for more, thanks a lot sir!

By: James Ashenhurst

James Ashenhurst — Wed, 15 May 2019 02:26:24 +0000

In reply to Anna. Oh dear. You are right. Let me look into that typo and fix... Thank you Anna!

By: Anna

Anna — Fri, 17 Mar 2017 02:28:32 +0000

Hi!
The reagent guide is amazing!!!
One thing that I noticed that is a bit confusing is that on page 104 it says: “Due to carbon’s higher electronegativity relative to Cu, it bears a partial positive charge and is thus nucleophilic.”
A partial positive isn’t what makes the carbon nucleophilic…. it’s the partial negative on the carbon! That’s obviously associated with the partial positive on the Copper, but Copper isn’t the nucleophile here. Clearing that up would be super helpful. :)

By: Kalairubin

Kalairubin — Thu, 22 Dec 2016 16:01:11 +0000

Thanks for the post it’s an awesome way to learn the reagents quickly!!!

By: Kristin

Kristin — Mon, 19 Sep 2016 01:41:09 +0000

There is a typo on page 41 on the explanation for example 7…
Purpose is spelled “purpsoe”!

By: Omkar Dedge

Omkar Dedge — Sun, 23 Aug 2015 11:03:32 +0000

Found Useful.Thanks!!!!

By: James

James — Fri, 24 Apr 2015 15:14:14 +0000

In reply to Amelia. It's available as a physical book on Amazon

By: Amelia

Amelia — Mon, 20 Apr 2015 05:20:46 +0000

Is this only sold as a pdf file or can this be bought as a physical hand-held book?

By: Aamir

Aamir — Sun, 01 Jun 2014 21:33:40 +0000

This and the summary sheets have been extremely useful!!! So invaluable thank you so much for creating this must have taken a lot of effort! Greatly appreciated