Comments on: Intramolecular Reactions of Alcohols and Ethers https://www.masterorganicchemistry.com/2015/06/12/intramolecular-reactions-of-alcohols-and-ethers/ Tue, 23 Jan 2024 20:42:15 +0000 hourly 1 https://wordpress.org/?v=6.6.2 By: d.arockiasamy https://www.masterorganicchemistry.com/2015/06/12/intramolecular-reactions-of-alcohols-and-ethers/#comment-669556 Sat, 02 Sep 2023 13:55:08 +0000 https://www.masterorganicchemistry.com/?p=8960#comment-669556 i have gone through your website. explanation is very good. eventhough i want basic mechanism and explanation for all reactions.

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2015/06/12/intramolecular-reactions-of-alcohols-and-ethers/#comment-551247 Tue, 02 Apr 2019 03:13:46 +0000 https://www.masterorganicchemistry.com/?p=8960#comment-551247 In reply to Anthacus.

Thanks Anthacus. Fixed now.

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2015/06/12/intramolecular-reactions-of-alcohols-and-ethers/#comment-551246 Tue, 02 Apr 2019 03:13:36 +0000 https://www.masterorganicchemistry.com/?p=8960#comment-551246 In reply to alexander Stein.

I think this has been fixed.

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2015/06/12/intramolecular-reactions-of-alcohols-and-ethers/#comment-551245 Tue, 02 Apr 2019 03:10:00 +0000 https://www.masterorganicchemistry.com/?p=8960#comment-551245 In reply to Jacob Grimm.

Hi Jacob – the problem is that it’s an alkane and there’s nothing to attack (i.e. no good leaving group!) . Breaking C-Br is OK because it liberates Br(-) [a weak base]. Breaking C-H is bad because it would have to liberate H(-) [a strong base]. Weak bases are good leaving groups!

]]> By: Jacob Grimm https://www.masterorganicchemistry.com/2015/06/12/intramolecular-reactions-of-alcohols-and-ethers/#comment-550633 Mon, 25 Mar 2019 18:07:08 +0000 https://www.masterorganicchemistry.com/?p=8960#comment-550633 On the last intramolecular rxn wouldn’t the nucleophile attack the 6 of the iso-propyl group due to proximity (takes less E) rather than the 6 of the alkane chain as shown? You get the same product but as far as mechanism goes, mine is better.

]]> By: alexander Stein https://www.masterorganicchemistry.com/2015/06/12/intramolecular-reactions-of-alcohols-and-ethers/#comment-495876 Thu, 08 Dec 2016 03:13:06 +0000 https://www.masterorganicchemistry.com/?p=8960#comment-495876 can’t see the images at the beginning of post. When i click on where they should be a .tif file downloads to my computer

]]> By: Anthacus https://www.masterorganicchemistry.com/2015/06/12/intramolecular-reactions-of-alcohols-and-ethers/#comment-472109 Mon, 08 Aug 2016 15:16:43 +0000 https://www.masterorganicchemistry.com/?p=8960#comment-472109 Just a quick thing, there are some broken pictures in The Intramolecular Williamson Ether Synthesis section.

]]> By: James https://www.masterorganicchemistry.com/2015/06/12/intramolecular-reactions-of-alcohols-and-ethers/#comment-405482 Mon, 15 Jun 2015 15:28:28 +0000 https://www.masterorganicchemistry.com/?p=8960#comment-405482 In reply to mamid.

Fixed. Thank you very much for your corrections, as always.

]]> By: mamid https://www.masterorganicchemistry.com/2015/06/12/intramolecular-reactions-of-alcohols-and-ethers/#comment-404866 Sat, 13 Jun 2015 17:23:33 +0000 https://www.masterorganicchemistry.com/?p=8960#comment-404866 Excellent post, as usual.
Some minor observations:
– in the last reaction scheme, the substrate (a.k.a. starting material, for young readers) is missing an isopropyl group; also the 5-methyl group in the product is drawn at an incorrect angle (perhaps on purpose?);
– it looks like you forgot to erase some “scribbled” notes at the end of the post.
Keep up the good work.

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