Comments on: Grossman’s Rule

By: James Ashenhurst

James Ashenhurst — Fri, 18 Nov 2022 21:53:49 +0000

In reply to Dr. Jim Romano,,,,,Orgoman. Lots of useful nuggets in there. The rule of thumb about reactions being reversible if the products differ in pKa by 8 is also a good one, as is "the second-best rule".

By: Dr. Jim Romano,,,,,Orgoman

Dr. Jim Romano,,,,,Orgoman — Fri, 18 Nov 2022 21:21:28 +0000

The book is fantastic,,,,,I have multiple copies of it in my offices in New York and Virginia.

By: Hormuzd Mulla

Hormuzd Mulla — Tue, 19 Sep 2017 05:45:57 +0000

I was one of the lucky ones to be part of Grossman’s Organic chemistry course that taught writing reasonable reaction mechanisms at the University of Kentucky. Back then, the book was called ‘class notes’ which were freely available on his website. However, I have bought both editions of his book and have recommended it to countless others as one of the finest books to invest in, if one really wants to learn how to write ‘reasonable’ reaction mechanisms. I am currently using the book as a guideline to teach a course on writing mechanisms to lab chemists at a company I consult at. I hope he comes out with a third edition. The problem sets are a treat for organic chemistry geeks.

By: Named Reactions 2: Break It Down Now « B.R.S.M.

Named Reactions 2: Break It Down Now « B.R.S.M. — Sun, 25 Mar 2012 21:10:23 +0000

[…] which obviously isn't in the product. Initially, it's not so obvious how to do this, and Grossman’s rule is a must. As you can draw a nice 6-membered transition state for this, I like to think of this as […]

By: james

james — Mon, 10 Oct 2011 15:12:16 +0000

In reply to wolfak.

Yep, there’s a lot – I could write about a dozen blog posts just based on the first chapter alone. I love the “common error alerts”.

By: wolfak

wolfak — Thu, 06 Oct 2011 11:53:31 +0000

I love this book! It’s great for intermediate studies in o-chem. There are several more rules in the text if I recall correctly. :)