Comments on: The Robinson Annulation https://www.masterorganicchemistry.com/2018/12/10/the-robinson-annulation/ Sun, 24 Mar 2024 14:31:28 +0000 hourly 1 https://wordpress.org/?v=6.6.2 By: James Ashenhurst https://www.masterorganicchemistry.com/2018/12/10/the-robinson-annulation/#comment-688683 Sun, 24 Mar 2024 14:31:28 +0000 https://www.masterorganicchemistry.com/?p=12136#comment-688683 In reply to Olivia.

Thank you! Fixed

]]> By: Olivia https://www.masterorganicchemistry.com/2018/12/10/the-robinson-annulation/#comment-688646 Sun, 24 Mar 2024 03:19:16 +0000 https://www.masterorganicchemistry.com/?p=12136#comment-688646 The link for the Michael addition post in related articles does not work (still found it through Google search but wanted to let you know). This website has been an absolute lifesaver, thank you for all that you do :)

]]> By: JKN https://www.masterorganicchemistry.com/2018/12/10/the-robinson-annulation/#comment-654408 Sun, 07 May 2023 12:15:36 +0000 https://www.masterorganicchemistry.com/?p=12136#comment-654408 Thanks James sir! Was a new topic for me but I’ve got it now

]]> By: Burgei Emanuel https://www.masterorganicchemistry.com/2018/12/10/the-robinson-annulation/#comment-640094 Wed, 12 Oct 2022 15:09:44 +0000 https://www.masterorganicchemistry.com/?p=12136#comment-640094 This is a well detailed notes.
It clearly explain and demonstrate Robinson annulation. Nice one

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2018/12/10/the-robinson-annulation/#comment-634443 Mon, 01 Aug 2022 20:18:32 +0000 https://www.masterorganicchemistry.com/?p=12136#comment-634443 In reply to John C..

Hard to generalize. Are you planning on a michael addition to an alpha-beta unsaturated ketone or a an alpha beta unsaturated aldehyde? If you’re using the ketone, the conjugate addition pathway should be fine (I’d be more conerned about an aldol if it was to an aldehyde).
Keep in mind that with a Stork enamine you are going to make the less-substituted enamine, so that is another thing to consider.

Is this for a reaction you are going to perform in the lab or is this “on paper”?

]]> By: John C. https://www.masterorganicchemistry.com/2018/12/10/the-robinson-annulation/#comment-634386 Sun, 31 Jul 2022 10:56:51 +0000 https://www.masterorganicchemistry.com/?p=12136#comment-634386 First time commenting here. May I know if using a Stork enamine reaction in the Michael addition step will lead to a higher yield of the bicyclic product? I have read that enolates are not particularly good Michael donors so they will favor the attack of the carbonyl carbon to undergo an aldol condensation instead of a Michael reaction.

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2018/12/10/the-robinson-annulation/#comment-633553 Wed, 20 Jul 2022 18:54:17 +0000 https://www.masterorganicchemistry.com/?p=12136#comment-633553 FIXED

]]> By: Anonymous https://www.masterorganicchemistry.com/2018/12/10/the-robinson-annulation/#comment-623072 Sun, 20 Mar 2022 02:57:53 +0000 https://www.masterorganicchemistry.com/?p=12136#comment-623072 Can you please post answers for the retrosynthetic Robinson annulation? Thanks

]]> By: Mitali https://www.masterorganicchemistry.com/2018/12/10/the-robinson-annulation/#comment-607070 Mon, 18 Oct 2021 15:38:37 +0000 https://www.masterorganicchemistry.com/?p=12136#comment-607070 Thank you so much for such a detailed explanation!!

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2018/12/10/the-robinson-annulation/#comment-600692 Thu, 06 May 2021 17:47:44 +0000 https://www.masterorganicchemistry.com/?p=12136#comment-600692 In reply to Kim Simons.

Thank you and I am very glad you find the site helpful. James

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