Comments on: Decarboxylation

By: 5 Easy Steps to Decarboxylate Your Weed - flowerz™

5 Easy Steps to Decarboxylate Your Weed - flowerz™ — Mon, 19 Feb 2024 07:44:58 +0000

[…] (pronounced de-carb-OX-yl-a-tion) is a very sciencey-sounding word for a relatively simple process. Decarboxylation is the process that activates the […]

By: Everything You Need to Know About THCA Flower : Woman of Many Roles

Everything You Need to Know About THCA Flower : Woman of Many Roles — Wed, 26 Jul 2023 22:19:48 +0000

[…] the compound doesn’t produce psychoactive effects in its raw form is essential. THCA must be decarboxylated through heat application to convert into THC, which can bind to your body’s endocannabinoid […]

By: James Ashenhurst

James Ashenhurst — Fri, 07 Jul 2023 20:52:09 +0000

In reply to Mikel Do.

Hi – yes, that’s a typo! Should be “azide” not “acide” :-)

By: Mikel Do

Mikel Do — Fri, 07 Jul 2023 17:15:44 +0000

Hello!
In §8 you discuss a Curtius rearrangement in which an acyl azide is heated and rearranged into an isocyanate, losing N2 in the process.
However, in the corresponding diagram, you draw a molecule subtitled “Acyl acid”… Is this an oversight or is there another explanation?

By: James Ashenhurst

James Ashenhurst — Mon, 08 May 2023 11:47:29 +0000

In reply to Deepak Thakur. Depends on structure, but at the end of it, there are lots of mild room-temperature protocols for basic ester hydrolysis (LiOH, H2O/THF) that will give you the carboxylic acid at the end. Acidic hydrolysis generally involves heat and with heat comes decarboxylation.

By: Deepak Thakur

Deepak Thakur — Mon, 08 May 2023 06:22:02 +0000

Let’s say I plan out a synthesis that involves the formation of beta keto carboxylic acid as a product (like in Doebner modification of Knoevenagel condensation), what are the methods to make sure that this acid doesn’t decarboxylate? Will low temperature (like room temperature) do the trick? Or will I need to choose a specific solvent system?

By: 5 Easy Steps to Decarboxylate Your Weed - flowerz

5 Easy Steps to Decarboxylate Your Weed - flowerz — Thu, 02 Mar 2023 17:31:12 +0000

[…] (pronounced de-carb-OX-yl-a-tion) is a very sciencey-sounding word for a relatively simple process. Decarboxylation is the process that activates the […]