Comments on: Aldol Addition and Condensation Reactions

By: Madhav Mittal

Madhav Mittal — Fri, 28 Jun 2024 08:19:48 +0000

If we got a methyl ethyl ketone, and have to perform aldol (by treating with OH-) , I think we will form form the thermodynamic enolate and then proceed. But my instructor states that the methyl’s carbon will get deprotonated because then we will get a 1° degree carbanion that will be more stable than 2°.I am super confused, please help me out.

By: Milad

Milad — Mon, 12 Feb 2024 10:55:25 +0000

Hello, below the notes (The Elimination Step In The Aldol Condensation Reaction) you made the arrow toward the enolate longer than the arrow in the opposite direction. it’s a mistake right ?

By: tej gandhi

tej gandhi — Wed, 07 Feb 2024 16:01:18 +0000

that LOL NO was epic lmao. ill never forget cross aldol again

By: James Ashenhurst

James Ashenhurst — Thu, 25 Aug 2022 07:53:50 +0000

In reply to Robert Zulu. Glad you find it helpful Robert!

By: Robert Zulu

Robert Zulu — Thu, 25 Aug 2022 02:21:18 +0000

So powerful and informative!

By: James Ashenhurst

James Ashenhurst — Mon, 20 Jun 2022 17:53:09 +0000

In reply to Alexander Walczak. Glad you found it helpful Alexander - 99% of people don't read down to the notes, but I am thankful for the small percentage (like you) who do!

By: Alexander Walczak

Alexander Walczak — Mon, 20 Jun 2022 15:13:58 +0000

Thanks for Note 8 about aldolase. I was confused about how 1,6-fructose bisphosphate was an aldol because textbooks always draw it in ring form. Makes a lot of sense, now!

By: Sudais

Sudais — Fri, 10 Jun 2022 16:27:13 +0000

Very amazing