Comments on: Fischer Esterification – Carboxylic Acid to Ester Under Acidic Conditions https://www.masterorganicchemistry.com/2022/11/16/fischer-esterification/ Sat, 09 Sep 2023 10:25:50 +0000 hourly 1 https://wordpress.org/?v=6.6.2 By: James Ashenhurst https://www.masterorganicchemistry.com/2022/11/16/fischer-esterification/#comment-670779 Sat, 09 Sep 2023 10:25:50 +0000 https://www.masterorganicchemistry.com/?p=26143#comment-670779 In reply to Sivesh.

The carbonyl carbon would not be activated towards.attack. The reaction would be slower.

Protonation of the carbonyl oxygen weakens the C-O pi bond and makes the carbonyl carbon more electrophilic.

]]> By: Sivesh https://www.masterorganicchemistry.com/2022/11/16/fischer-esterification/#comment-670776 Sat, 09 Sep 2023 09:30:39 +0000 https://www.masterorganicchemistry.com/?p=26143#comment-670776 In the mechanism, what if the oxygen of hydroxyl moiety was protonated first instead of the carbonyl oxygen?

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