Comments on: Nucleophilic Addition To Carbonyls https://www.masterorganicchemistry.com/2022/09/09/nucleophilic-addition/ Sun, 09 Jun 2024 19:27:34 +0000 hourly 1 https://wordpress.org/?v=6.6.2 By: James Ashenhurst https://www.masterorganicchemistry.com/2022/09/09/nucleophilic-addition/#comment-696274 Sun, 09 Jun 2024 19:27:34 +0000 https://www.masterorganicchemistry.com/?p=26141#comment-696274 In reply to Madhav Mittal.

Neutral nucleophiles can certainly add to carbonyls – for example, water forms hydrates with aldehydes and ketones. It’s just slower.

As far as the formation of the alkoxide, keep in mind that a proton transfer will result in a neutral addition product.

]]> By: Madhav Mittal https://www.masterorganicchemistry.com/2022/09/09/nucleophilic-addition/#comment-695928 Thu, 06 Jun 2024 06:29:20 +0000 https://www.masterorganicchemistry.com/?p=26141#comment-695928 Can I conclude from this that a neutral nucleophile will never perform an addition reaction on carbonyl group ( because what we will form will be an alkoxide ion which will be definitely stronger base than a neutral nucleophile)

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