Comments on: SN1 vs E1 and SN2 vs E2 : The Temperature

By: Madhav Mittal

Madhav Mittal — Thu, 16 May 2024 07:12:30 +0000

In note 3, when we treated secondary alkyl halide with weak base , how did SN2 dominate?
As the base/nucleophile is weak(neutral) so it should be SN1,right?

By: Madhav Mittal

Madhav Mittal — Wed, 15 May 2024 18:09:59 +0000

Dr James, please also tell that if we are given a chair conformation of cyclohexane, will we have to do the reaction with that particular conformation only , or can we do ring flipping?

By: James Ashenhurst

James Ashenhurst — Thu, 30 Nov 2023 19:25:02 +0000

In reply to Areeba. It means 80% ethanol, 20% water. E.g. 800 mL EtOH and 200 mL H2O.

By: James Ashenhurst

James Ashenhurst — Thu, 30 Nov 2023 19:24:29 +0000

In reply to Arpit Rath. Since this is a secondary alkyl iodide, and there is a tertiary carbon adjacent to the secondary alkyl halide, my guess is that the heat is just helping the secondary alkyl halide form a carbocation. I would suggest that after formation of the carbocation you will get a hydride shift, followed by attack of tBuOH on to the tertiary carbocation.

By: Arpit Rath

Arpit Rath — Sat, 27 Feb 2021 03:57:01 +0000

Hey i have a question. If i treat 2-iodo-3,4-dimethylpentane with tertiary butyl alcohol under sufficiently high temperature, what will be the major product? I’m struggling to know whether it’ll be an E1 or E2 product. Could you help me out here please ??

By: James Ashenhurst

James Ashenhurst — Fri, 05 Feb 2021 18:35:09 +0000

In reply to Len. You are correct. Fixed. Thank you so much Len!

By: Len

Len — Fri, 05 Feb 2021 04:13:28 +0000

Hi James, impressive amount of work in this site. On this page, I think the last two diagrams in the Notes section are out of sequence. The word heat is NOT omitted where the narrative says it is and vice-versa. (Or maybe I misunderstand your point!)

By: Aman Gandhi

Aman Gandhi — Tue, 05 Jan 2021 18:21:42 +0000

I think the last two images should replace each other. Since the last reaction should have ‘heat’ written on the arrow .
Thanks for the Post.

By: Nikhilesh

Nikhilesh — Fri, 21 Aug 2020 07:25:33 +0000

This site is just marvellous I never think of it thank u sir

By: James Ashenhurst

James Ashenhurst — Sat, 16 May 2020 03:39:22 +0000

In reply to Meow. I would assume that "mild heat" is there for a purpose, and it is pushing towards E1.